Cancer-related fatigue is the most common and often the most distressing side effect experienced by people with cancer, including melanoma. It is different from the fatigue everyone has from time to time; it is usually more severe, lasts longer, and can take a heavy toll on your quality of life. Resting more or doing less does not make it go away. You may not have the energy to accomplish all of your daily tasks. That’s okay. There are strategies you can use to manage fatigue, save energy, and take steps to reduce fatigue. Here are some tips.